微密圈

A 微密圈 alumnus and professor have been awarded U.S. Patent No. 8,598,150 for use of an antioxidant compound that shows promise in the treatment of obesity and related disorders, such as type-2 diabetes.

The researchers鈥擩onathan R. Brestoff Parker, a 2008 graduate who is currently a trustee of the College, and Thomas H. Reynolds, associate professor of health and exercise sciences鈥攄iscovered that treating obese mice with an antioxidant called MnTBAP* decreases obesity and improves type-2 diabetes.

Obese mice that received the compound lost 40 percent of their body weight. 鈥淭o put that number in context, if a 300-pound obese person lost 40 percent of their body weight, they would have lost 120 pounds,鈥� said Brestoff Parker.

The compound works by breaking down triglycerides, which are stored in excess in fat tissue of obese people. The researchers鈥� next step, according to Reynolds, is 鈥渢o figure out how that happens. What are the cellular and molecular events that result in weight loss?鈥� He calls this stage of drug development 鈥渢he fun part of science鈥攖rying to design the next study that will yield information about how a biological system responds to a drug.鈥�